CAS:188627-80-7Eptifibatide

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Eptifibatide 依非巴特,埃替非巴肽,安普利肽 Cat No. FB01351Cas No. 188627-80-7

Eptifibatide is a specific inhibitor of fibrinogen working by binding to the platelet membrane integrin αIIbβ3 receptor and preventing platelet aggregation.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2020 mL
- 6.0099 mL
- 12.0198 mL
- 5 mM
- 0.2404 mL
- 1.2020 mL
- 2.4040 mL
- 10 mM
- 0.1202 mL
- 0.6010 mL
- 1.2020 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

188627-80-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C35H49N11O9S2

运输

蓝冰

分子量

831.96

别名

溶解度

DMSO	50.0 mg/mL (60.1 mM) warming
Water	10.0 mg/mL (12.0 mM) warming

动物实验配方

靶点数据

生物活性

描述Glycoprotein (GP) IIb/IIIa complexe is responsible for the formation of platelet aggregates and the adhesion of platelets to uncovered collagen fibers in the injured vessel wall. Eptifibatide is a potent antagonist of GPIIb/IIIa complex. It dose-dependently reduced the adhesion of collagen-activated platelets to a fibrinogen-coated surface with a concentration of 4-38μg/mL and the approximate IC₅₀ value was 11μg/mL. Eptifibatide at 4-52µg/mL reduced thrombin, collagen, and ADP-induced platelet aggregation in a concentration-dependent manner with estimated IC₅₀ values of 16, 25, and 27µg/mL for ADP, collagen and thrombin, respectively. In addition, eptifibatide at 52µg/mL reduced lysosome secretion induced by ADP, collagen and thrombin by 70, 60, and 50 %, respectively. Eptifibatide binds to GPIIb/IIIa complex with an K_D value of 120nM. In a mouse model of cecal slurry-induced sepsis, intravenous administration of eptifibatide (15µg/g, three times) resulted in lower sepsis scores and better survival when compared with vehicle-treated group.
动物研究
剂量
Rat: 2 mg/ml/kg^[3] (i.v.)

给药途径
i.v.

动物药代数据
Animal Rats^[3]
Dose 2 mg/ml/kg
Administration i.v.
T_1/2 0.131 h
T_max 2.00 min
AUC_0-73h 0.895 μg·h/ml
C_max 7.10 μg/ml