CAS:65678-07-1AG1024

Synonyms: Tyrphostin;AGS-200;Tyrphostin AG-1024

AG1024 inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

65678-07-1

储存条件

分子式

C14H13BrN2O

运输

蓝冰

分子量

305.17

别名

Tyrphostin;AGS-200;Tyrphostin AG-1024

溶解度

动物实验配方

生物活性

靶点 Insulin Receptor

IC50:57μM IGF-1R

IC50:7μM
描述IGF-1R (insulin-like growth factor-1 receptor) plays a key role in transformation, growth and survival of malignant cells, and has been considered as a general and promising target for cancer treatment. AG1024 is a selective IGF-1R inhibitor with IC50 value of 7μM for inhibition of IGF-1R autophosphorylation in NIH-3T3 cells, also inhibits IR with IC50 of 57μM. AG1024 inhibited the IGF-1-induced MAPK signal-regulated kinase pathway in metastatic melanoma cells (501 mel) treated with 4μM AG1024 for 30min. And a longer treatment of AG1024 led to a restore of pRb tumor suppressive function as the reduction in the phosphorylated forms of pRb, p107 and p130 due to proteasomal and nonproteasomal degradation, and the formation of growth suppressive DNA binding complexes consisting of pRb and E2F1 or E2F3 could be observed^[2].
动物研究
剂量
Nude Mice: 1.5 mg/kg^[3] (i.p.); 100 mg/kg^[4] (p.o.)

给药途径
i.p., p.o.

靶点	Description	IC50
Insulin Receptor		IC50:57μM
IGF-1R		IC50:7μM