CAS:1799328-86-1ASTX660

您的位置 : 首页 / Apoptosis / IAP / ASTX660

ASTX660 ASTX660 Cat No. FB11531Cas No. 1799328-86-1

An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8529 mL
- 9.2647 mL
- 18.5293 mL
- 5 mM
- 0.3706 mL
- 1.8529 mL
- 3.7059 mL
- 10 mM
- 0.1853 mL
- 0.9265 mL
- 1.8529 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1799328-86-1

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C30H42FN5O3

运输

蓝冰

分子量

539.68

别名

溶解度

DMSO	97.0 mg/mL (179.7 mM)
Water	Insoluble
Ethanol	97.0 mg/mL (179.7 mM)

动物实验配方

靶点数据

生物活性

描述An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities. Upon administration, XIAP/cIAP1 antagonist ASTX660 selectively binds to and inhibits the activity of XIAP and cIAP1. This restores and promotes the induction of apoptotic signaling pathways in cancer cells, and inactivates the nuclear factor-kappa B (NF-kB)-mediated survival pathway. XIAP and cIAP1 are overexpressed by many cancer cell types and suppress apoptosis by inhibiting the activity of certain caspases; they promote both cancer cell survival and chemotherapy resistance.