CAS:1333327-56-2TRC051384 Hydrochloride

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TRC051384 HCl TRC051384盐酸盐 Cat No. FB11256Cas No. 1333327-56-2

TRC051384 is an inducer of heat shock protein Hsp70. it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9920 mL
- 9.9600 mL
- 19.9199 mL
- 5 mM
- 0.3984 mL
- 1.9920 mL
- 3.9840 mL
- 10 mM
- 0.1992 mL
- 0.9960 mL
- 1.9920 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	1333327-56-2	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C25H32ClN5O4	运输	蓝冰
分子量	502.01	别名

靶点数据

生物活性

描述TRC051384 is a potent inducer of HSP70 which can induce HSP70B mRNA expression. Dose-dependent increase of HSP70B can be observed on mRNA level in both HeLa and mixed neuronal cells exposure to 6.25μM and 12.5μM TRC051384 for 4h. Consistent with this, TRC051384 at 25μM can increase the transcriptional activity of HSF-1, the protein HSP70 as the chaperone responsible for, in luciferase assay reporter systems in HeLa cells, as well as lead to a significant recovery from a heat shock. Administration of TRC051384 intraperitoneally significantly reduced stroke associated neuronal injury and disability in a rat model of transient ischemic stroke. Meanwhile the enhanced expression of HSP70 can be observed in the affected region of rats dosed with TRC051384^[1]. Administration with 9mg/kg TRC051384 could delayed thrombus formation in mice^[2].
动物研究
剂量
Mice^[2] (i.p.): 9 mg/kg

给药途径
i.p.

动物药代数据
Animal Rats^[1]
Dose 9 mg/kg
Administration i.p,
T_1/2 2 h
T_max 15 min