CAS:302803-72-1Ciliobrevin A

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Synonyms: Hedgehog Pathway Inhibitor 4;HPI-4

Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

302803-72-1

储存条件

分子式

C17H9Cl2N3O2

运输

蓝冰

分子量

358.18

别名

Hedgehog Pathway Inhibitor 4;HPI-4

溶解度

DMSO	160.0 mg/mL (446.7 mM)
Water	insoluble

动物实验配方

生物活性

描述The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Ciliobrevin A is an Hh signaling pathway inhibitor with an IC₅₀ value less than 10 μM. Ciliobrevin A prevents an increase in the FLAG-Gli2 full-length/repressor ratio upon Shh stimulation. Ciliobrevin A also perturbs primary cilia formation in the Shh-LIGHT2_FLAG-Gli1 cells and promotes accumulation of FLAG-Gli1 at the distal tip of this organelle. Ciliobrevin A significantly inhibits the proliferation of these neuronal progenitors, as measured by histone H3 phosphorylation (pH3) levels, and reduces cellular levels of cyclin D1 protein and Gli1, Gli2, and N-Myc transcripts in the CGNPs. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. Hh downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). In zebrafish models, HPI-4 can effectively prevent pancreatic fibrosis and destruction.