Coumarins
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00925 | Xanthotoxol | 2009-24-7 | Xanthotoxol, a natural product isolated and purified from the fruits of Cnidium monnieri, has neuroprotection, due to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia. |
| FB01823 | Umbelliferone | 93-35-6 | Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells. |
| FB09096 | Methoxsalen | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| FB01686 | Isofraxidin | 486-21-5 | Isofraxidin, a natural product isolated and purified from the herbs of Sarcandra glabra (Thunb.) Nakai, possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2. |
| FB02012 | Fraxin | 524-30-1 | Fraxin protects HUVECs from oxidative stress, enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. It is a natural product isolated and purified from the bark of Fraxinus brngeana DC.. |
| FB02011 | Fraxidin | 525-21-3 | Fraxidin is a natural product isolated and purified from the herbs of Sarcandra glabra. |
| FB06813 | Fraxetin | 574-84-5 | Fraxetin, a natural product isolated and purified from the bark of Fraxinus brngeana DC., has protective against rotenone-induced cytotoxicity, apoptotic death and antioxidant activities. |
| FB09320 | Esculetin | 305-01-1 | Esculetin is a naturally occuring 5-lipoxygenase and 12-Lipoxygenase inhibitor with IC50 values of ID50 values of 4 and 2.5 µM, respectively. |
| FB05734 | Dimethylfraxetin | 6035-49-0 | Dimethylfraxetin is a natural product isolated and purified from the herbs of Viola yedonensis Makino with anti-HRV-2 activity. |
| FB00554 | Dihydrocoumarin | 119-84-6 | Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics. |
| FB00204 | Daphnoretin | 2034-69-7 | Daphnoretin, a natural product isolated and purified from the roots of Wikstroemia indica (Linn.) C. A. Mey., has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin also has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way. |
| FB02229 | Coumestrol | 479-13-0 | Coumestrol, a natural product isolated and purified from the herbs of Erythrina arborescens, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. |
| FB00001 | Coumarin | 91-64-5 | Coumarin is a secondary phytochemical isolated and purified from the herbs of Melilotus officinalis with hepatotoxic and carcinogenic properties. |
| FB02181 | Citropten | 487-06-9 | Citropten, a natural product isolated and purified from the peel of Citrus medica L., has interactions with human malignant melanoma A-2058 cells which are exposed to them. |
| FB08192 | Bergaptol | 486-60-2 | Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM. |
| FB07866 | Auraptene | 495-02-3 | Auraptene is a natural product isolated and purified from the peel of Poncirus trifoliata with anti-tumor and anti-oxidant activity. Auraptene-mediated activation of JNK may contribute to the production of Aβ by promoting γ-secretase activity. |
| FB00926 | 8-Geranyloxypsoralen | 7437-55-0 | 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits β-secretase (BACE1) activity in non-competitive manner, with the IC(50) values < 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg/ L against B. xylophilus and is 117.5 mg/L against P. redivivus. |
| FB03499 | 8-Geranyloxy-5,7-Dimethoxycoumarin | 1228175-65-2 | 8-Geranyloxy-5,7-dimethoxycoumarin is a natural product isolated and purified from the herbs of Toddalia asiatica with antidiabetic and antioxidant effect. |
| FB03519 | 8-(6-Hydroperoxy-3,7-Dimethyl-2,7-Octadienyloxy)psoralen | 151121-39-0 | 8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen is a natural product isolated and purified from the herbs of Psoralea corylifolia L.. |
| FB01410 | 7-Methoxycoumarin | 531-59-9 | 7-Methoxycoumarin, a natural product isolated and purified from the herbs of Citrus reticulata cv. Chachiensis, has potent antioxidant effect, strong hepatoprotective activity, and weak estrogenic activity. |
| FB01004 | 7-Hydroxy-6-Methoxy-3-Prenylcoumarin | 299159-90-3 | 7-Hydroxy-6-methoxy-3-prenylcoumarin is a natural product isolated and purified from the herbs of Coriaria nepalensis. |
| FB01512 | 7-Amino-4-Methylcoumarin | 26093-31-2 | 7-Amino-4-methylcoumarin is a natural product isolated and purified from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. It is also a reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins' monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye. |
| FB10487 | 5-Methoxypsoralen | 484-20-8 | 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line. |
| FB01619 | 4-Methylumbelliferone | 90-33-5 | 4-Methylumbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. |
| FB03503 | (S)-Yuehgesin C | 125072-68-6 | (S)-Yuehgesin C is a natural product isolated and purified from the herbs of Murraya paniculata. |