CAS:1943733-16-1YU238259

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YU238259 is an inhibitor of homology-dependent DNA repair.

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

技术信息

CAS号

1943733-16-1

储存条件

分子式

C22H22ClN3O4S

运输

蓝冰

分子量

459.95

别名

溶解度

DMSO	50.0 mg/mL (108.7 mM)
Water	insoluble

动物实验配方

生物活性

描述YU238259 is a novel DNA double-strand break repair inhibitor exhibiting potent synthetic lethality in the setting of DNA damage response and DNA repair defects. YU238259 specifically inhibits homology-dependent DNA repair, but not non-homologous end-joining, in cell-based GFP reporter assays at concentration of 5μM. Treatment with YU238259 was not only synergistic with ionizing radiation, etoposide, and PARP inhibition, but this synergism was heightened by BRCA2 deficiency. Also it significantly delayed growth of BRCA2-deficient human tumor xenografts in nude mice through administration at dose of 3mg/kg, i.p., 3 days per week for 12 doses, even in the absence of concomitant DNA-damaging therapy.
动物研究
剂量
Mice: 3 mg/kg, 5 mg/kg^[1] (i.p.)

给药途径
i.p.