CAS:83480-29-9Voglibose

Synonyms: AO 128

Voglibose, an N-substituted derivative of valiolamine, can inhibit α-glucosidase and be used to treat hyperglycemia and its concomitant diseases.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

83480-29-9

储存条件

分子式

C10H21NO7

运输

蓝冰

分子量

267.28

别名

AO 128

溶解度

DMSO	74.0 mg/mL (276.9 mM)
Ethanol	Insoluble

动物实验配方

生物活性

描述D-Glucose and insulin levels of plasma are usually high in diabetics especially after food ingestion, and reducing intestinal carbohydrate absorption, such as monosaccharides, which are hydrolyzed by α-glucosidase, is one way to control disorders of carbohydrate metabolism. Voglibose, a α-glucosidase inhibitor, delays the digestion and absorption of carbohydrates and is the aid in the treatment of diabetes^[3]. In the case of postprandial glucose excursion, oral administration of voglibose (0.2 mg/kg) reduced the carbohydrate-induced increase in blood glucose without causing sustained hypoglycemia in both normal and neonatal streptozotocin-induced diabetic rats^[4]. In prediabetic db/db mice, voglibose decreased the average food consumption by 37% compared with vehicle-treated mice. Furthermore, voglibose treatment increased GLP-1 (glucagon-like peptide-1) secretion, while it decreased plasma glucose-dependent insulinotropic polypeptide (GIP)^[5].