CAS:137862-53-4Valsartan

Synonyms: CGP 48933

Valsartan is a selective angiotensin II AT1 receptor antagonist with elimination half-life‎ of ‎6 hours.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

137862-53-4

储存条件

分子式

C24H29N5O3

运输

蓝冰

分子量

435.52

别名

CGP 48933

溶解度

动物实验配方

生物活性

描述Valsartan is a blocker in angiotensin II receptor used in the treatment of hypertension and congestive heart failure, with IC₅₀ ranging from 39.5 to116 uM. In vitro,Valsartan (50 μM) induced a significant increase in p-AMPK and p-LKB1.Valsartan inhibited NF - κ B activity and significantly reduced the expression and activity of inflammatory cytokines, TLR-4, TF induced by Hg. The main antihypertensive effect of valsartan is mediated by a reduction in angiotensin II activation of the AT1-R in vascular smooth muscle. The peak plasma concentration (C max) of valsartan occurs within 2-4 h after dosing, and absolute bioavailability is roughly 25%.