CAS:178606-66-1U-104

Synonyms: MST-104;NSC-213841

U-104 is a potent carbonic anhydrase (CA) inhibitor with Ki of 45.1 nM and 4.5 nM for CA IX and CA XII, respectively.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

178606-66-1

储存条件

分子式

C13H12FN3O3S

运输

蓝冰

分子量

309.32

别名

MST-104;NSC-213841

溶解度

DMSO	50.0 mg/mL (161.6 mM)
Water	insoluble

动物实验配方

30% PEG400+0.5% Tween80+5% propylene glycol+water

30 mg/mL

suspension

生物活性

描述CAIX (Carbonic anhydrase IX) is a hypoxia and HIF-1–inducible protein that regulates intra- and extracellular pH under hypoxic conditions and promotes tumor cell survival and invasion in hypoxic microenvironments. U-104 is a novel ureido-sulfonamide inhibitor of CAIX and CAXII with Ki values of 45.1nM and 4.5nM, respectively. Administration of U-104 daily significantly inhibited primary tumor growth in the mice injected with a highly metastatic variant of the MDA-MB-231 cell line with robustly induced CAIX in hypoxia. Also, it resulted the inhibition of metastases formation of mice intravenous injected with 4T1 cells.
动物研究
剂量
Mice^[2] (p.o.): 38 mg/kg

给药途径
p.o.,