CAS:10405-02-4Trospium chloride

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Trospium chloride is a competitive antagonist at muscarinic cholinergic receptors, used to treat symptoms of an overactive bladder.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

10405-02-4

储存条件

分子式

C25H30ClNO3

运输

蓝冰

分子量

427.96

别名

溶解度

DMSO	41.0 mg/mL (95.8 mM)
Ethanol	42.0 mg/mL (98.1 mM)

动物实验配方

生物活性

描述Trospium Chloride is antagonist of acetylcholine muscarinic receptors and the cornerstone of pharmacotherapy for the symptoms of overactive bladder (OAB). Trospium chloride, dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. Moreover, trospium chloride (1 mg/kg, intravenously) permeation across the BBB (blood-brain barrier ) is not increased in ageing perse, and therefore, the occurrence of adverse CNS (central nervous system) drug effects is also not expected to increase with ageing.