CAS:440-17-5Trifluoperazine dihydrochloride

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Trifluoperazine 2HCl 盐酸三氟拉嗪 Cat No. FB05721Cas No. 440-17-5

Synonyms: SKF 5019;TFP

Trifluoperazine 2HCl is a dopamine D2 receptor inhibitor with anti-dopaminergic and anti-adrenergic actions, which belongs to the phenothiazine compounds.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0815 mL
- 10.4076 mL
- 20.8152 mL
- 5 mM
- 0.4163 mL
- 2.0815 mL
- 4.1630 mL
- 10 mM
- 0.2082 mL
- 1.0408 mL
- 2.0815 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

440-17-5

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C21H26Cl2F3N3S

运输

蓝冰

分子量

480.42

别名

SKF 5019;TFP

溶解度

DMSO	240.0 mg/mL (499.6 mM) warming
Water	100.0 mg/mL (208.2 mM)

动物实验配方

0.5% CMC-Na

15 mg/mL

suspension

靶点数据

生物活性

描述Trifluoperazine dihydrochloride (TFP) is an antipsychotic phenothiazine agent and a selective α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is also a potent dopamine D2 receptor inhibitor^[3]. Trifluoperazine, as an anxiolytic and antipsychotic agent, has been an extensively studied drug molecule that has been used as a calmodulin inhibitor^[4]. Trifluoperazine and chlorpromazine inhibited in a dose-dependent manner the stimulation of glycogenolysis, gluconeogenesis, and ureogenesis due to alpha 1-adrenergic stimulation in rat hepatocytes. Chlorpromazine and trifluoperazine are much more potent at alpha 1- than at alpha 2-adrenergic receptors^[3]. Larger doses of trifluoperazine (1.125-4.5 mg/kg) totally inhibited apomorphine-induced (0.125 mg/kg, s.c.) stereotypy in both groups^[5].