CAS:2398-96-1Tolnaftate

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Tolnaftate is a synthetic thiocarbamate-derived antifungal.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

2398-96-1

储存条件

分子式

C19H17NOS

运输

蓝冰

分子量

307.41

别名

溶解度

动物实验配方

生物活性

描述Tolnaftate, is a topical antifungal agent described to be effective in the treatment of otomycosis^[3]. Cells grown in the presence of tolnaftate (at the IC50) showed a reduced content of total phospholipids and sterols whereas there was an increase in total RNA content. The activity of membrane-bound enzymes did not change on treatment with tolnaftate (10 x MIC) whereas an increase in the leakage of intracellular 32P was observed. Activity of phosphodiesterase decreased and 5'-nucleotidase increased in tolnaftate-resistant cells^[4]. In vitro skin penetration studies revealed that after application of 1% (w/w) tolnaftate solution in polyethylene glycol 400 for 24 hours, the mean amount of tolnaftate penetrating into the epidermis and dermis was 2.60 +/- 0.28 mg/cm² and 0.92 +/- 0.12 mg/cm², respectively^[5]. The thiocarbamate antimycotics tolnaftate and tolciclate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. The biochemical action of tolnaftate and tolciclate is thus similar to that of the allylamine antimycotics naftifine and terbinafine^[6].