CAS:1616632-77-9TIC10

Synonyms: ONC-201

TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

1616632-77-9

储存条件

分子式

C24H26N4O

运输

蓝冰

分子量

386.49

别名

ONC-201

溶解度

DMSO	50.0 mg/mL (129.4 mM) warming
Water	insoluble

动物实验配方

生物活性

描述TRAIL is an endogenous protein that induces fulminant tumor-specific apoptosis through binding to death receptors DR4 or DR5 expressed in human tumor cells. TIC10 is a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL. TIC10, which is the most potent inducer of cell death, exclusively activate Foxo3a through inactivation of Akt/ERK to upregulate TRAIL and its pro-apoptotic death receptor DR5. In a vivo experiment, TIC10 induced a delayed and modest amount of cell death that was apparent at 72 hours post-treatment with a 1 μM dose. TIC10 can synergistically inhibit Panc-1 xenograft growth in SCID mice. TIC10 at 5-25 μM significantly decreased viability of Panc-1 cells.
动物研究
剂量
Mice: 25 mg/kg - 100 mg/kg^[1] (i.v.); 25 mg/kg^[1] (p.o.); 100 mg/kg^[1] (i.p.)

给药途径
i.v., p.o., i.p.

动物研究
剂量	Mice: 25 mg/kg - 100 mg/kg^[1] (i.v.); 25 mg/kg^[1] (p.o.); 100 mg/kg^[1] (i.p.)
给药途径	i.v., p.o., i.p.