CAS:925705-73-3TG 100713

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TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

925705-73-3

储存条件

分子式

C12H10N6O

运输

蓝冰

分子量

254.25

别名

溶解度

动物实验配方

生物活性

靶点 PI3Kα

IC50:165nM PI3Kβ

IC50:215nM PI3Kδ

IC50:24nM PI3Kγ

IC50:50nM
描述The phosphoinositide 3-kinase (PI3K) signaling pathway plays a central role in regulating cell growth, proliferation, survival, angiogenesis, metabolism, and motility. The class I PI3-Ks (p110α, p110β, p110δ, and p110γ) are activated by tyrosine kinases or G protein-coupled receptors to generate PIP3, which engages downstream effectors such as the Akt/PDK1 pathway, the Tec family kinases, and the Rho family GTPases. TG100713 is a pan-PI3K inhibitor with IC₅₀s of 50 nM, 24 nM, 165 nM and 215 nM for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ, respectively. In a vitro study, TG 100713 at 10 M strongly inhibited human umbilical vein endothelial cell proliferation.