CAS:91161-71-6Terbinafine

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Terbinafine 特比萘芬 Cat No. FB04114Cas No. 91161-71-6

Synonyms: SF 86-327

Terbinafine is a naphthalene-derived allylamine antifungal, working by inhibiting squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes.

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18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4314 mL
- 17.1568 mL
- 34.3136 mL
- 5 mM
- 0.6863 mL
- 3.4314 mL
- 6.8627 mL
- 10 mM
- 0.3431 mL
- 1.7157 mL
- 3.4314 mL
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技术信息

CAS号

91161-71-6

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C21H25N

运输

蓝冰

分子量

291.43

别名

SF 86-327

溶解度

DMSO	57.0 mg/mL (195.6 mM)
Water	Insoluble
Ethanol	57.0 mg/mL (195.6 mM)

动物实验配方

靶点数据

生物活性

描述Terbinafine, an allylamine antifungal used orally and topically is considered to be a first-line drug in the therapy of dermatophyte infections. Terbinafine resistance has been predominately attributed to point mutations in the squalene epoxidase (SQLE) target gene a key enzyme in the ergosterol biosynthetic pathway leading to single amino acid substitutions^[3]. Terbinafine has primarily fungicidal action against many fungi as a result of its specific mechanism of squalene epoxidase inhibition. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida (Ki = 30 nM) ^[4]. Terbinafine belongs to the drugs able to induce subcutaneous lupus erythematosus (SCLE)-with a relatively high risk. Therefore, terbinafine should be prescribed with caution in patients who show light sensitivity, arthralgias, positive antinuclear antibodies or have a history of SLE or SCLE^[5].