CAS:145733-36-4Tasosartan

Synonyms: WAY-ANA 756

Tasosartan is a long-acting angiotensin II receptor blocker.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

145733-36-4

储存条件

分子式

C23H21N7O

运输

蓝冰

分子量

411.46

别名

WAY-ANA 756

溶解度

DMSO	120.0 mg/mL (291.6 mM) warming

动物实验配方

生物活性

描述Tasosartan is a long-acting angiotensin II (AngII) receptor blocker. Each metabolite of Tasosartan bound the human A-II receptor with IC(50)s between 20 and 45nM. In vivo, tasosartan (100 mg p.o. and 50 mg i.v) blocked by 80% AT1(AngII subtype-1) receptors 1 to 2 h after drug administration and still had a 40% effect at 32 h. in vitro, the blockade was estimated to be 90% at 2 h and 20% at 32 h. Tasosartan at dosages of 10, 30, 100, or 300 mg given once daily produced a significant and dose-related reduction in both clinic and ambulatory BP(blood pressure) that was maintained over the 24-h period.