CAS:6080-33-7Sinomenine Hydrocloride

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Sinomenine HCl 盐酸青藤碱 Cat No. FB09334Cas No. 6080-33-7

Synonyms: Cucoline HCl;Kukoline HCl;Sabianine A HCl

Sinomenine Hydrocloride is a an alkaloid found in the root of the climbing plant Sinomenium acutum which has anti-inflammatory effects in several animal models of inflammation and inhibits mast cell degranulation and histamine release. It is used to treat inflammatory diseases like rheumatoid arthritis.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7334 mL
- 13.6668 mL
- 27.3336 mL
- 5 mM
- 0.5467 mL
- 2.7334 mL
- 5.4667 mL
- 10 mM
- 0.2733 mL
- 1.3667 mL
- 2.7334 mL
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技术信息

CAS号

6080-33-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C19H24ClNO4

运输

蓝冰

分子量

365.85

别名

Cucoline HCl;Kukoline HCl;Sabianine A HCl

溶解度

DMSO	73.0 mg/mL (199.5 mM)

动物实验配方

靶点数据

生物活性

描述Sinomenine, a nature compound existing in sinomenium acutum, has many biological activity, such as anti-cancer activity. In vitro studies, sinomenine HCl could inhibit the growth, migration, invasiveness and angiogenesis in clear-cell renal cell carcinoma cells^[1]. Besides this, it was found that sinomenium acutum could also suppress the viability of U87 and SF767 cell, through ROS generation and autophagy-lysosome pathway activation^[2]. In vivo studies, sinomenine HCl has the ability of improving survival, reducing organ damage and attenuating the release of inflammatory cytokines in BALB/c mice with sepsis induced by cecal ligation and puncture (CLP), partially by regulating autophagy activities^[3]. In addition, sinomenine HCl could contribute to the improvement of some clinical symptoms in rat model of renal fibrosis, induced by adriamycin^[4].