CAS:305834-79-1SC79

SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

305834-79-1

储存条件

分子式

C17H17ClN2O5

运输

蓝冰

分子量

364.78

别名

溶解度

DMSO	110.0 mg/mL (301.6 mM)
Water	insoluble

动物实验配方

2% DMSO+corn oil

5 mg/mL

生物活性

描述Akt/PKB is the major molecular in the PI3K pathway. It contains a PH domain that specifically binds PtdIns(3,4,5)P3 on the plasma membrane, which guides AKT to the cell membrane in a process mediated by interaction with the phospholipids then switches AKT to an active form. Elevation of Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. SC79 is a pan-Akt activator, though it suppresses AKT PH-domain plasma membrane translocation. In multiple cell lines, treatment with 1-4ug/ml SC79 can dramatically increase p-AKT. SC79 treatment (4μg/ml) can reduce the hippocampal neuron death induced by glutamate. Intraperitoneal injection of 40mg/kg SC79 can prevent stroke induced Akt deactivation and neuronal death in brain of mouse ischemia model. This also hinted that SC79 was brain-penetrable^[1].
作用机制SC79 can directly bind to AKT and convert AKT to an active conformation, which is more suitable to be phosphorylated by upstream kinases.^[1]