CAS:1333210-07-3SAR7334

Synonyms: SAR 7334

SAR7334 is a potent TRPC6 (Transient receptor potential cation channel, subfamily C, member 6) inhibitor.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

1333210-07-3

储存条件

分子式

C21H22ClN3O

运输

蓝冰

分子量

367.87

别名

SAR 7334

溶解度

动物实验配方

生物活性

描述The cation channel transient receptor potential canonical (TRPC) 6 has been associated with several pathologies including focal segmental glomerulosclerosis, pulmonary hypertension and ischaemia reperfusion-induced lung oedema. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca²⁺ influx into cells with IC₅₀s of 9.5, 282 and 226 nM. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀ of 7.9 nM. In most TRPC6-HEK-FITR cells, trypsin evoked large, rapidly declining TRPC6 currents that reached an almost steady-state level within 30–60 s. This current was substantially reduced by 100 nM SAR7334. The reduction of trypsin-induced TRPC6 currents by 100 nM SAR7334 amounted to 88 ± 3% (n = 5). In perfused isolated lungs from mice, SAR7334 abolished hypoxia-induced increases in pulmonary arterial pressure. Half maximal inhibition was achieved at about 100 nM indicating that SAR7334 is able to efficiently block native TRPC6 channels in situ^[3].