CAS:483-14-7Rotundine

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Rotundine 罗通定 Cat No. FB09089Cas No. 483-14-7

Rotundine is antagonist for domapmine D1 receptor(Ki = 124 nM) and has a lower binding activity of domapmine D2 receptor and domapmine D3 receptor. It can also inhibit 5-HT1A (Ki = 340 nM).

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8135 mL
- 14.0676 mL
- 28.1351 mL
- 5 mM
- 0.5627 mL
- 2.8135 mL
- 5.6270 mL
- 10 mM
- 0.2814 mL
- 1.4068 mL
- 2.8135 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

483-14-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C21H25NO4

运输

蓝冰

分子量

355.43

别名

溶解度

DMSO	205.0 mg/mL (576.8 mM) warming
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM. Rotundine (l-THP) possesses a blocking effect on dopamine D1 and D2 receptors and can inhibit physical dependence in morphine dependent mice and significantly reduce the development of the conditional place preference induced by morphine in mice^[3]. Rotundine (6.25, 12.5 mg/kg) does not affect the magnitude of sensitization, but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75 mg/kg)+oxycodone+oxycodone group, indicating that Rotundine (18.75 mg/kg) greatly inhibits the development of oxycodone sensitization^[4]. The various types of NOS (nitric oxide synthase) play different roles in the lung damages after brain I/R (ischemia/reperfusion) injury at different stages in rats. Rotundine injection can ameliorate the damages by modulating the activities of different types of NOS^[5]. Compared with the control group, rotundine(> or = 17.1 mg/kg) inhibited gastric acid and decreased secretion of gastric juice(P < 0.01), but had no influence on pepsin activity^[6].