CAS:91374-20-8Ropinirole Hydrochloride

Synonyms: SKF 101468A;SKF-101468 HCl

Ropinirole HCl selectively inhibit dopamine D2 receptor with Ki of 29 nM. It is used for the treatment of spontaneous parkinson's disease.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

91374-20-8

储存条件

分子式

C16H25ClN2O

运输

蓝冰

分子量

296.84

别名

SKF 101468A;SKF-101468 HCl

溶解度

动物实验配方

生物活性

描述Ropinirole (Hydrochloride), a selective agonist of dopamine D2/D3, is in use for the treatment of parkinsonism^[3]. Ropinirole decreased ICSS (intracranial self-stimulation) thresholds and induced anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory. Ropinirole significantly affects emotionality at doses (1-10 mg/kg, i.p.) that exert no robust effects on locomotion or cognition^[4]. Ropinirole transiently increased premature responses, a measure of motor impulsivity, and this change was larger and more long-lasting in the cued task^[5]. Ropinirole hydrochloride potentially targets multiple mechanisms of ALS (amyotrophic lateral sclerosis) pathology (i.e., oxidative stress, mitochondrial dysfunction, and abnormal aggregation of TDP-43/FUS protein, which is representative of the ALS phenotype), with promising preclinical study results based on iPSC (induced pluripotent stem cells) research^[6].