CAS:19396-06-6Polyoxin B

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Synonyms: Polyoxin-B

Polyoxin B is a competitive inhibitor of chitin synthetase.

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描述Polyoxin B acts as an competitive inhibitor of chitin synthetase, which is concerned in the synthesis of cell-wall chitin of A. kikuchiana. The polyoxin-resistance of this fungus is caused by a lowered penetration of the antibiotic through the cell membrane into the enzyme site. In vitro，polyoxin B, at a concentration of 10 μM, inhibited more than 50% of the incorporation of glucosamine-14C into cell-wall chitin in washed mycelia of the polyoxin-sensitive strains and at the same time resulted in an unusually increased accumulation of UDP-N-acetylglucosamine-14C, which is a precursor of chitin biosynthesis^[3].