CAS:1383716-40-2PIK-III

您的位置 : 首页 / PI3K/Akt/mTOR / PI3K / PIK-III

PIK-III PIK-III Cat No. FB10193Cas No. 1383716-40-2

Synonyms: VPS34-IN2

PIK-III, which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1312 mL
- 15.6561 mL
- 31.3123 mL
- 5 mM
- 0.6262 mL
- 3.1312 mL
- 6.2625 mL
- 10 mM
- 0.3131 mL
- 1.5656 mL
- 3.1312 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1383716-40-2

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C17H17N7

运输

蓝冰

分子量

319.36

别名

VPS34-IN2

溶解度

DMSO	138.0 mg/mL (432.1 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. PIK-III is an autophagy inhibitor which can acutely inhibit autophagy and de novo lipidation of LC3, and lead to the stabilization of autophagy substrates. PIK-III could modulate PtdIns(3)P-mediated effectors in mammalian cells. The IC₅₀s of PIK-III are 0.018 μM, 1.2 μM, 3.04 μM, 3.96 μM and 4.43 μM for Vps34, PI3Kδ, PI3Kγ, PI3Kα and PI4Kβ, respectively. In a vitro study, CD34 ⁺ cells were treated ex vivo for 48h with PIK-III (5 µM). The reduction in engrafted cells following single PIK-III treatment, including primitive CD34⁺CD38^- and CD34⁺CD133⁺ populations, confirmed the essential role of autophagy in the maintenance of the LSC pool.