CAS:900185-02-6PIK-294

您的位置 : 首页 / PI3K/Akt/mTOR / PI3K / PIK-294

PIK-294 is a potent and selective p110δ inhibitor with IC50 of 10 nM while 10,000/490/160 nM for p110α/β/γ.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

900185-02-6

储存条件

分子式

C28H23N7O2

运输

蓝冰

分子量

489.53

别名

溶解度

DMSO	205.0 mg/mL (418.8 mM)
Water	insoluble

动物实验配方

生物活性

描述The phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway is one of the most frequently dysregulated signaling cascades in human malignancies, it displays oncogenic potential and it is implicated in a wide variety of different neoplasms. The PI3-K family comprises 15 kinases with distinct substrate specificities, expression patterns, and modes of regulation. The class I PI3-Ks (p110α, p110β, p110δ, and p110γ) are activated by tyrosine kinases or G protein-coupled receptors to generate PIP3, which engages downstream effectors such as the Akt/PDK1 pathway, the Tec family kinases, and the Rho family GTPases. PIK-294 is one of the most potent p110δ-selective inhibitors with IC50s of 0.01 μM for p110δ and 10 μM ,0.49 μM, 0.16 μM for p110α, p110β and p110γ. In a vitro experiment, pretreatment with the PI3kinase p110δ inhibitor PIK-294 10 μM can significantly inhibited GM-CSF mediated phosphorylation in Neutrophils. The involvement of PI3Kδ in chemotaxis as pre-treatment of the cells with the PI3Kδ selective inhibitor PIK-294 significantly reduced migration in response to stimulation with CXCL8.