CAS:92-84-2Phenothiazine

Synonyms: ENT 38

Phenothiazine, a dopamine2 (D2) receptor antagonist, could reduce the expression of dopamine in the brain.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

92-84-2

储存条件

分子式

C12H9NS

运输

蓝冰

分子量

199.27

别名

ENT 38

溶解度

DMSO	290.0 mg/mL (1455.3 mM)
Water	insoluble

动物实验配方

生物活性

描述Phenothiazines are associated with elevated serum prolactin, which can suppress fertility in some species. Long-acting neuroleptic drugs reduce the adrenal stress response, but may interfere with reproductive responses and negatively influence breeding success^[3]. Clinical use of N-substituted phenothiazines as antihistaminics (1940s), sedatives and antipsychotics (1950s) followed and continues to this day^[4]. The synthesis of a series of novel phenothiazine compounds that inhibit the growth of both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The more potent phenothiazine derivatives were more active against chloroquine-sensitive parasites than against chloroquine-resistant parasites and showed little synergy of action when used in combination with chloroquine^[5].