CAS:58-39-9Perphenazine

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Perphenazine 过非那嗪 Cat No. FB08142Cas No. 58-39-9

Synonyms: Perphenazin

Perphenazine is an inhibitor of 5-HT2A receptor(5-HT2A), alpha-1A adrenergic receptor (α1A), dopamine D2 receptor/dopamine D3 receptor, D2L receptor, and Histamine H1 receptor ( Kis = 5.6, 10, 0.765/0.13, 3.4, and 8 nM respectively). It is commonly used as a typical antipsychotic drug.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4754 mL
- 12.3772 mL
- 24.7544 mL
- 5 mM
- 0.4951 mL
- 2.4754 mL
- 4.9509 mL
- 10 mM
- 0.2475 mL
- 1.2377 mL
- 2.4754 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

58-39-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C21H26ClN3OS

运输

蓝冰

分子量

403.97

别名

Perphenazin

溶解度

DMSO	67.0 mg/mL (165.9 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Perphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively^[3]. There is evidence that perphenazine is effective in the prevention of PONV (postoperative nausea and vomiting) in children and adults without serious adverse effects compared with placebo^[4]. Doses of up to 20 mg perphenazine kg-1 day-1, injected on days 1-7, prolonged gestation but the mothers and young were apparently normal; lower doses were effective only when treatment commenced soon after copulation. Perphenazine delays and prevents implantation in rats by counteracting oestrogen release from the ovaries^[5]. In addition, Perphenazine enhanced the expression of CD71 on K562 cells (leukemia cells) and increased Hb content in K562 cells, while inhibited the proliferation of K562 cells. K562 cells showed differentiation morphology after the drug treatment^[6].