CAS:350997-39-63,4-Dichlorobenzo[b]thiophene-2-carbohydrazide

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OGG1 Inhibitor O8 3,4-二氯苯并[b]噻吩-2-甲酰肼 Cat No. FB16844Cas No. 350997-39-6

O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG1-mediated catalysis but did not reduce DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8295 mL
- 19.1477 mL
- 38.2954 mL
- 5 mM
- 0.7659 mL
- 3.8295 mL
- 7.6591 mL
- 10 mM
- 0.3830 mL
- 1.9148 mL
- 3.8295 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	350997-39-6	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C9H6Cl2N2OS	运输	蓝冰
分子量	261.13	别名

靶点数据

生物活性

描述The base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of oxidatively induced lesions in cellular DNA. 8-oxoguanine DNA glycosylase-1 (OGG1) is the human DNA glycosylase responsible for removal of the highly mutagenic 7,8-dihydro-8-oxoguanine (8-oxo-Gua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) lesions from DNA. O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35 μM in fluorescence-based OGG1 assays^[1]. Mechanism: OGG1 Inhibitor O8 inhibits OGG1 through the inhibition of Schiff base formation during OGG1 catalysis^[1].