CAS:66-71-71,10-Phenanthroline

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o-Phenanthroline 1,10-菲罗啉 Cat No. FB16631Cas No. 66-71-7

Synonyms: 1,10-Phenanthroline

o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.5492 mL
- 27.7461 mL
- 55.4923 mL
- 5 mM
- 1.1098 mL
- 5.5492 mL
- 11.0985 mL
- 10 mM
- 0.5549 mL
- 2.7746 mL
- 5.5492 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

66-71-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C12H8N2

运输

蓝冰

分子量

180.21

别名

1,10-Phenanthroline

溶解度

DMSO	34.0 mg/mL (188.7 mM)
Water	Insoluble
Ethanol	35.0 mg/mL (194.2 mM)

动物实验配方

靶点数据

生物活性

描述O-phenanthroline is a non-specific matrix metalloproteinase (MMP) inhibitor. O-phenanthroline reduced the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. Interestingly, O-phenanthroline significantly inhibited matrix degradation in a TNFα/IL-1β-dependent model of cartilage degeneration when compared to control and natural hypoxia (2.5% O2 ). Additionally, O-phenanthroline alleviated MMP-induced cartilage degradation without affecting chondrogenesis in the explant culture^[2]. The lethal effect could be explained by the kinetics of reaction of o-phenanthroline with intracellular Fe2+, i.e., the mono and bis complexes are more reactive than intracellular Fe2+^[3]. H2O2 is able to induce mutation at the HGPRT locus in V79 cells and morphological transformation of C3H/10T1/2 cells. O-Phenanthroline abolishes both effects, indicating that hydroxyl radical is directly involved in mutation and carcinogenesis^[4].