CAS:1400-61-9Nystatin

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Synonyms: Fungicidin

Nystatin is a polyene antifungal drug used to treat fungal infections of the mouth, skin, vagina, and intestinal tract.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

1400-61-9

储存条件

分子式

C47H75NO17

运输

蓝冰

分子量

926.09

别名

Fungicidin

溶解度

DMSO	50.0 mg/mL (54.0 mM) warming

动物实验配方

生物活性

描述Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six Candida species^[3]. Histopathological results showed that liposomal nystatin cleared the lungs, spleen, pancreas, kidney, and liver of Aspergillus and that there was no organ damage at the day 5 time point, which was after only three doses of liposomal nystatin. Based on these results in mice, it is probable that liposomal nystatin will be effective against Aspergillus infection in humans^[4]. Nystatin-enhanced internalization of endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. More importantly, combined treatment with nystatin and endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo^[5].