CAS:1418013-75-8NMS-873

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NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

1418013-75-8

储存条件

分子式

C27H28N4O3S2

运输

蓝冰

分子量

520.67

别名

溶解度

动物实验配方

生物活性

靶点 p97

IC50:20nM
描述P97 is an AAA+ ATPase regulating endoplasmic reticulum–associated degradation. NMS-873 is a potent and selective p97 ATPase allosteric inhibitor with IC50 value of 30 nM, selective over all other AAA ATPases, HSP90 and kinases tested with IC50 >10 μM. NMS-873 exhibited antiproliferation on HCT116 cancer cell line cells with IC50 value of 0.4μM. It induced clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at concentration at 0.5, 2.5 and 5μM in HCT116 cells at 8h and 24h post treatment^[1]. NMS-873 also showed potent HCMV antiviral effect with potential as a novel host targeting therapeutic for HCMV infection. Pretreatment with NMS-873 at 1μM clearly inhibited the production of infectious virus in human primary fibroblast cells infected at high multiplicity of infection with HCMV^[2]
作用机制NMS-873 is a non–ATP-competitive p97 inhibitor with a new allosteric mechanism.^[1]