CAS:249537-73-3NFAT INhibitor

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NFAT Inhibitor NFAT INhibitor Cat No. FB15260Cas No. 249537-73-3

Synonyms: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

NFAT Inhibitor is a high-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.5938 mL
- 2.9692 mL
- 5.9385 mL
- 5 mM
- 0.1188 mL
- 0.5938 mL
- 1.1877 mL
- 10 mM
- 0.0594 mL
- 0.2969 mL
- 0.5938 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

249537-73-3

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C75H120N20O22S

运输

蓝冰

分子量

1685.94

别名

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

溶解度

Water

100.0 mg/mL (59.3 mM) warming

动物实验配方

靶点数据

生物活性

描述The nuclear factor of activated T cells (NFAT) is a family of transcription factors that regulate immune responses and adaptive response in skeletal and cardiac muscle. NFAT inhibitor (VIVIT peptide) is a cell-permeable peptide that selectively inhibits calcineurin-mediated dephosphorylation of NFAT^[1]. In peripheral blood CD14+ monocytes isolated from rheumatoid arthritis patients, treatment with 10μM of NFAT inhibitor plus 100ng/mL of recombinant human RANKL and 50ng/mL of M‐CSF for 24h significantly inhibited nuclear translocation of NFATc1, but not that of peroxisome proliferator-activated receptor γ coactivator 1β. Long-term (21 days) treatment with NFAT inhibitor in combination with M‐CSF and RANKL significantly inhibited the cytoplasmic levels of cathepsin K, tartrate‐resistant acid phosphatase, and matrix metalloproteinase 9^[2]. Intraperitoneal administration of NFAT (10mg/kg) once daily for 2 days prevented T-cell activation and proliferation in C3H/HeN mice^[3].
作用机制NFAT inhibitor potently and selectively inhibits the NFAT-calcineurin interaction without affecting calcineurin phosphatase activity. It was developed based on the conserved calcineurin docking site of NFAT^[1].