CAS:130773-02-3Neticonazole hydrochloride

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Synonyms: SS 717

Neticonazole HCl is an imidazole antifungal for the treatment of fungal skin infections.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

130773-02-3

储存条件

分子式

C17H23ClN2OS

运输

蓝冰

分子量

338.90

别名

SS 717

溶解度

DMSO	215.0 mg/mL (634.4 mM) warming
Water	240.0 mg/mL (708.2 mM)

动物实验配方

生物活性

描述Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the pathology of CRC^[1]. Neticonazole hydrochloride is a imidazole derivative and a potent and long-acting antifungal agent^[2]. Neticonazole is also a novel exosome secretion inhibitor. In IDB mice bearing CRC xenograft tumors, IDB promoted CRC xenograft tumor growth and exosome secretion, which could be inhibited by the exosome secretion inhibitor neticonazole. Moreover, neticonazole treatment significantly improved the survival of IDB mice with CRC xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells^[1]. In animals treated with 1% neticonazole cream, a significant mycological improvement was observed when compared to untreated controls. The mycological result of the neticonazole solution treated group was significantly superior to those of the untreated control group, the solution vehicle-treated group and the BFZ (bifonazole) solution-treated group^[3].