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NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM.1 It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors
规格 | 价格 | 促销价格 | 库存 |
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18817579266
实验数据
技术信息
CAS号 | 1916571-90-8 | 储存条件 |
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分子式 | C20H23F3N4S | 运输 | 蓝冰 | |||||
分子量 | 408.48 | 别名 | ||||||
溶解度 |
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动物实验配方 |
生物活性
动物研究 | |
剂量 | Mice: 40 mg/kg[2] (i.p.) |
给药途径 | i.p. |