CAS:1394371-75-54-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide

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nAChR agonist 1 4-(5-(4-氯苯基)-4-甲基-2-丙酰基噻吩-3-基)苯磺酰胺 Cat No. FB17206Cas No. 1394371-75-5

nAChR agonist 1 is a novel positive allosteric modulator of α7 nAChR. It has shown excellent safety profile in phase 1 clinical trials and is being evaluated for efficacy and safety as monotherapy in patients with mild to moderate Alzheimer's disease.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3813 mL
- 11.9063 mL
- 23.8127 mL
- 5 mM
- 0.4763 mL
- 2.3813 mL
- 4.7625 mL
- 10 mM
- 0.2381 mL
- 1.1906 mL
- 2.3813 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	1394371-75-5	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C20H18ClNO3S2	运输	蓝冰
分子量	419.94	别名

靶点数据

生物活性

描述The α7 nicotinic acetylcholine receptor (α7 nAChR) is a subtype of nAChRs that plays a key role in the pathophysiology of neuropsychiatric diseases. nAChR agonist 1, also known as DUN71755, is a potent, orally bioavailable, and brain-permeable, allosteric α7 nAChR agonist. The EC50 value of nAChR agonist 1 is 0.32 µM in a Ca²⁺ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells expressing α7 nAChR. The oral bioavailability of nAChR agonist 1 in rats was 74%. nAChR agonist 1 showed excellent brain availability and brain residence time in rats. nAChR agonist 1 at 30 mg/kg had no significant CNS liabilities in locomotor activity, motor coordination, and MES/PTZ-induced seizure tests in rats^[1].