CAS:2231744-29-7MT-802

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MT-802 MT-802 Cat No. FB11880Cas No. 2231744-29-7

MT-802 (MT802) is a potent BTK PROTAC that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM); MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome; MT-802 binds fewer off-target kinases than ibrutinib does and retains an equivalent potency (>99% degradation at nanomolar concentrations) against wild-type and C481S BTK, elicits complete BTK knockdown at 250 nM; reduces the pool of active, phosphorylated BTK in cells isolated from CLL patients with the C481S mutation, whereas ibrutinib cannot.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2693 mL
- 6.3466 mL
- 12.6933 mL
- 5 mM
- 0.2539 mL
- 1.2693 mL
- 2.5387 mL
- 10 mM
- 0.1269 mL
- 0.6347 mL
- 1.2693 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	2231744-29-7	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C41H41N9O8	运输	蓝冰
分子量	787.82	别名

靶点数据

生物活性

描述MT-802 (MT802) is a potent BTK PROTAC that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM); MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome; MT-802 binds fewer off-target kinases than ibrutinib does and retains an equivalent potency (>99% degradation at nanomolar concentrations) against wild-type and C481S BTK, elicits complete BTK knockdown at 250 nM; reduces the pool of active, phosphorylated BTK in cells isolated from CLL patients with the C481S mutation, whereas ibrutinib cannot.