CAS:2070014-87-6MRT68921 hydrochloride

您的位置 : 首页 / Autophagy / ULK / MRT68921 HCl

Synonyms: MRT68921 HCl

MRT68921 HCl is a selective inhibitor of ULK1 and ULK2 with IC50 0f 2.9 nM and 1.1 nM.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

2070014-87-6

储存条件

分子式

C25H35ClN6O

运输

蓝冰

分子量

471.04

别名

MRT68921 HCl

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

生物活性

描述ULK1 (unc-51-like kinase 1), a serine/threonine protein kinase, is essential for the initial stages of autophagy and can be targeted to block autophagy for disease therapy. MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC₅₀ for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM). In line with the in vitro IC₅₀ values, 1 μM MRT68921 was sufficient to reduce phospho-ATG13 which was used as a measure of ULK1 activity to control levels. Therefore, this compound could reduce ULK1 activity in cells. Importantly, it also blocked autophagy as indicated by LC3-II levels.