CAS:15622-65-8Molindone Hydrochloride

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Molindone HCl 盐酸吗茚酮 Cat No. FB06316Cas No. 15622-65-8

Synonyms: EN-1733A

Molindone HCl, the salt form of molindone which is a dopamine receptor antagonist, can be used in the treatment of schizophrenia and act as a therapeutic antipsychotic.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1966 mL
- 15.9829 mL
- 31.9657 mL
- 5 mM
- 0.6393 mL
- 3.1966 mL
- 6.3931 mL
- 10 mM
- 0.3197 mL
- 1.5983 mL
- 3.1966 mL
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技术信息

CAS号

15622-65-8

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C16H25ClN2O2

运输

蓝冰

分子量

312.83

别名

EN-1733A

溶解度

DMSO	20.0 mg/mL (63.9 mM) warming
Water	125.0 mg/mL (399.6 mM)

动物实验配方

靶点数据

生物活性

描述Molindone hydrochloride, a dihydroindolone neuroleptic, is structurally distinct from other classes of neuroleptics. Molindone exhibits many similarities to other neuroleptics, including dopamine receptor blockade, antipsychotic efficacy, and extrapyramidal side effects. Clinically, molindone has a tendency to cause weight loss and may have less effect on seizure threshold than conventional antipsychotic agents^[3]. Molindone is a relatively safe neuroleptic for child and adolescent inpatients because of its short half-life and minimal prolonged tissue accumulation^[4]. Molindone at doses of 5-20 mg/day (children weighing <30 kg) and 20-40 mg (≥ 30 kg) was well tolerated, and preliminary efficacy results suggest that molindone produces dose-related behavioral improvements over 9-12 weeks^[5]. Once a patient's acute psychotic episode has been stabilized with intramuscular molindone, therapy can continue without interruption by substituting 1.5 mg of oral molindone for every 1 mg of intramuscular molindone. The time to maximum concentration occurred significantly earlier with intramuscular molindone (0.6 hours) than with oral molindone (1.1 hours) ^[6].