CAS:22916-47-8Miconazole

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Miconazole 1-[2-(2,4-二氯苯基)-2-[(2,4-二氯苯基)甲氧基]乙基]-1H-咪唑 Cat No. FB02454Cas No. 22916-47-8

Synonyms: Monistat;R18134

Miconazole is a synthetic imidazole-derived antifungal used in the treatment of candidal skin infections, selectively affecting the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4031 mL
- 12.0155 mL
- 24.0310 mL
- 5 mM
- 0.4806 mL
- 2.4031 mL
- 4.8062 mL
- 10 mM
- 0.2403 mL
- 1.2016 mL
- 2.4031 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

22916-47-8

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C18H14Cl4N2O

运输

蓝冰

分子量

416.13

别名

Monistat;R18134

溶解度

DMSO	83.0 mg/mL (199.5 mM)
Water	Insoluble
Ethanol	83.0 mg/mL (199.5 mM)

动物实验配方

靶点数据

生物活性

描述Miconazole is an imidazole antifungal agent. This agent is distinguished from other azoles by possessing two mechanisms of action. The first mechanism is shared with other azoles and involves the inhibition of ergosterol synthesis. Another mechanism involves inhibition of peroxidases, which results in the accumulation of peroxide within the cell resulting in cell death. Miconazole remains a highly prescribed treatment for vaginal candidiasis^[3]. Miconazole was more effective than nystatin for thrush. For HIV-infected patients, there was no significant difference in the efficacy between miconazole and other antifungals. For denture wearers, microwave therapy was significantly better than miconazole. No significant difference was found in the safety evaluation between miconazole and other treatments^[4]. In addition, miconazole promoted functional recovery on ischemic stroke model via stimulating post-ischemic neurogenesis^[5].