生物活性

• 描述Micafungin sodium is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis. Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. Micafungin as a potential agent for disrupting the structure of a biofilm of P. aeruginosa allowing the possible exposure and treatment of core-planktonic cells^[3]. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone^[4]. In AML (acute myeloid leukemia) patients, outcomes of prophylactic micafungin during induction chemotherapy did not differ significantly with those of prophylactic posaconazole with regard to incidence of fungal infections, rate of discontinuation, or safety. Prophylactic micafungin is safe and effective in patients with acute leukemia undergoing induction chemotherapy^[5]. In the first large observational study of micafungin treatment or prophylaxis conducted under real-world conditions in France, micafungin was effective and well tolerated for prophylaxis of invasive fungal infections in pediatric oncohematology patients and for curative purposes in pediatric and neonatal ICU patients^[6].