CAS:73-31-4Melatonin

Synonyms: N-Acetyl-5-Methoxytryptamine

Melatonin is a hormone which plays a role in natural sleep-wake cycle and also a ATF6 blocker.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

73-31-4

储存条件

分子式

C13H16N2O2

运输

蓝冰

分子量

232.28

别名

N-Acetyl-5-Methoxytryptamine

溶解度

DMSO	180.0 mg/mL (774.9 mM)
Ethanol	77.5 mg/mL (333.7 mM)

动物实验配方

生物活性

描述Activating transcription factor 6 (ATF-6) is one of the three main endoplasmic reticulum(ER) transmembrane sensors that elicit the unfolded protein response(UPR). Melatonin (N-acetyl-5-methoxytryptamine), produced in the human pineal gland during the night phase of the light-dark cycle, plays important roles in physiological and pharmacological functions and also acts as a novel selective ATF-6 inhibitor. Melatonin treatment (10^-5 mM) for 24 h after pretreatment by tunicamycin inhibited the expression COX-2 by downregulating ATF-6, which increased the apoptosis of HepG2 cells via CHOP and Bcl-2/Bax pathway. Melatonin was an effective free radical scavenger and antioxidant which reduced amyloid β protein toxicity of Alzheimer's disease, reduced oxidative damage in several models of Parkinson's disease, protected against glutamate excitotoxicity, reduced ischemia-reperfusion injury, lowered neural damage due to d-aminolevulinic acid (phorphyria), hyperbaric hyperoxia and a variety of neural toxins. It also had been shown to reduce lipid peroxidation and oxidative damage to nuclear DNA.
动物研究
剂量
Mice: 1 mg/kg - 50 mg/kg^[4] (i.p.)

给药途径
i.p.