CAS:826-39-1DL-Mecamylamine (hydrochloride)

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Mecamylamine HCl is a non-competitive nicotinic acetylcholine receptor antagonist with antidepressant-like effects in mice.

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描述Mecamylamine HCl is a nonselective and noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier^[1]. A dose-response study showed that mecamylamine significantly decreased immobility time in the TST (tail suspension test) at the 1.0 mg/kg dose but did not alter baseline locomotor activity. One milligram per kilogram of mecamylamine also significantly decreased time immobile in the FST (forced swim test) whereas both beta2- and alpha7-knockout mice were insensitive to the effects of mecamylamine in the FST^[2]. Mecamylamine, 230 mug/kg or greater, failed to diminish either the rate of spontaneous discharge of carotid body chemoreceptors at high arterial oxygen tensions (greater than 130 mm Hg), or the responses of these receptors to NaCN (0.5 - 25 mug), HCl or hypoxic blood. Responses of chemoreceptor afferent fibres to ACh (1.0 - 50 mug) in the same preparations were either completely abolished or considerably reduced by mecamylamine^[3].