CAS:114798-26-4Losartan

Synonyms: DuP-753

Losartan is a compeitive AT1 receptor inhibitor with IC50 value of 20 nM.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

114798-26-4

储存条件

分子式

C22H23ClN6O

运输

蓝冰

分子量

422.91

别名

DuP-753

溶解度

动物实验配方

生物活性

靶点 Angiotensin Receptor

IC50:20nM
描述Losartan, a small-molecule angiotensin II type 1 receptor antagonist used to treat hypertension. The concentration that inhibits 50% of the binding of angiotensin II (IC₅₀) is 20 nM. In vitro, losartan effectively limited the fibrotic potential of RDEB fibroblasts, as measured by cell contractility. In vivo, Losartan was filtered to a final concentration of 0.6 g/L, providing an estimated daily dose of 40-60 mg/kg/day. Losartan treatment prevented significant retinal ganglion cell loss and significantly lowered blood pressure. Losartan inhibited effects of glaucoma.