CAS:23672-07-3Levosulpiride

Synonyms: S-(-)-Sulpiride

Levosulpiride, an atypical antipsychotic, can selectively inhibit D2 receptor and it is the (S)-enantiomer of sulpiride.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

23672-07-3

储存条件

分子式

C15H23N3O4S

运输

蓝冰

分子量

341.43

别名

S-(-)-Sulpiride

溶解度

DMSO	650.0 mg/mL (1903.8 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	13 mg/mL	clear
PO	0.5% CMC-Na	40 mg/mL	suspension

生物活性

描述Levosulpiride, a newer prokinetic agent, selectively inhibits gut and central D2 receptors and is associated with various movement disorders like- tremor, Parkinsonism, dyskinesias and rarely dystonia^[3]. Dopamine is the main endogenous inhibitor of prolactin synthesis and secretion in the anterior pituitary. Levosulpiride causes significant elevation of serum prolactin levels in significant number of patients^[4]. Levosulpiride appears to be a well-tolerated and effective drug for the treatment for SDs (somatoform disorders). Levosulpiride significantly reduced the number of SD symptoms compared to placebo (P =0.007) after 4 weeks of treatment. Levosulpiride also determined a more evident reduction of the total number of SD symptoms compared to placebo^[5]. Levosulpiride frequently causes drug-induced movement disorders, presenting mainly with LIP followed by lower face dyskinesia. The symptoms are often severe, and irreversible even after the withdrawal of levosulpiride^[6].