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Inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. Additionally, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin.
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18817579266
实验数据
技术信息
CAS号 | 1228280-29-2 | 储存条件 |
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分子式 | C18H16N4O2S | 运输 | 蓝冰 | |||
分子量 | 352.41 | 别名 | ||||
溶解度 |
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动物实验配方 |
生物活性