CAS:241479-67-4Isavuconazole

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Synonyms: BAL-4815;RO 0094815

Isavuconazole is a broad-spectrum triazole antifungal agent used to treat invasive aspergillosis and invasive mucormycosis.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

241479-67-4

储存条件

分子式

C22H17F2N5OS

运输

蓝冰

分子量

437.47

别名

BAL-4815;RO 0094815

溶解度

DMSO	125.0 mg/mL (285.7 mM)
Water	insoluble

动物实验配方

生物活性

描述Isavuconazole, the active moiety of its prodrug isavuconazonium, is a new extended-spectrum triazole whose activity against yeasts, molds, including Aspergillus and mucorales, and dimorphic fungi has been shown in vitro and in preclinical models^[3]. Isavuconazole is highly active against Candida bloodstream isolates, including fluconazole-resistant strains. It was more active than itraconazole and voriconazole against C. albicans and C. glabrata. For isavuconazole, MIC(50)s/MIC(90)s ranged from 000.2/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata^[2]. Isavuconazole presents a very high oral absorption with no first-pass effect which is not interfered by the presence of food, gastric pH modifications, or mucositis. In addition, isavuconazole may inhibit CYP3A4 and induce CYP2B6 and P-glycoprotein^[4]. Isavuconazole showed activity against mucormycosis with efficacy similar to amphotericin B. Isavuconazole can be used for treatment of mucormycosis and is well tolerated^[5].