CAS:931398-72-0IOX2

IOX2 IOX2 Cat No. FB08949Cas No. 931398-72-0

Synonyms: JICL38

IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) Prolyl-Hydroxylases (PHD), and active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH(20uM).

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8382 mL
- 14.1908 mL
- 28.3816 mL
- 5 mM
- 0.5676 mL
- 2.8382 mL
- 5.6763 mL
- 10 mM
- 0.2838 mL
- 1.4191 mL
- 2.8382 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

931398-72-0

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C19H16N2O5

运输

蓝冰

分子量

352.34

别名

JICL38

溶解度

DMSO	7.0 mg/mL (19.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

5% DMSO+30% PEG 300+water

2 mg/mL

靶点数据

生物活性

靶点 PHD2/ELGN-1

IC50:21nM
描述The family of HIF-PH (HIF prolyl hydroxylase) enzymes are the main molecular to regulate HIF activity through hydroxylation at 2 proline residues and cause the degradation of HIF, thus leading to inhibition on accumulation of functional HIF under normoxia. IOX2 is a HIF-PH inhibitor with IC50 value of 22nM for PHD2. IOX2 showed selective inhibition of PHD catalysed HIF-1α prolyl-hydroxylation in a variety of human cell lines, including renal carcinoma (RCC4) cell line lacking VHL, 293T, U2OS and RCC4 re-expressing VHL (RCC4/VHL) cells, on dose of 50/250uM for 6h^[1]. Treatment of primary articular chondrocytes with IOX2, 20μM for 72h, promoted articular chondrocyte diﬀerentiation^[2].
作用机制IOX2 can form tight binding interactions with the catalytic iron and make a steric clash with the hydroxylated HIF-1α.^[1]
动物研究
剂量
Mice: 37.7 mg/kg^[2] (i.p.)

给药途径
i.p.

动物研究
剂量	Mice: 37.7 mg/kg^[2] (i.p.)
给药途径	i.p.