CAS:152918-18-8IB-MECA

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IB-MECA IB-MECA Cat No. FB01571Cas No. 152918-18-8

Synonyms: Piclidenoson;CF-101

IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM. IB-MECA is a potent and selective A3 adenosine receptor agonist with Ki value of 1.1, 54 and 56 nM for A3, A1 and A2A receptors, respectively, which possessing cardioprotective effect and reduces infarct size upon reperfusion in rats.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9597 mL
- 9.7984 mL
- 19.5969 mL
- 5 mM
- 0.3919 mL
- 1.9597 mL
- 3.9194 mL
- 10 mM
- 0.1960 mL
- 0.9798 mL
- 1.9597 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

152918-18-8

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C18H19IN6O4

运输

蓝冰

分子量

510.29

别名

Piclidenoson;CF-101

溶解度

DMSO	265.0 mg/mL (519.3 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

靶点 Adenosine Receptor A3

EC50:0.11μM
描述Adenosine receptors play an important role in cell growth and proliferation in different cell lines. The A₃ adenosine receptor (A₃AR) expression level in normal cells is low, while it is more highly expressed in various tumor cells. IB-MECA is a reversable A₃AR agonist, inhibiting the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostate. IB-MECA was able to inhibit forskolin-stimulated cyclic adenosine monophosphate (cAMP) levels with EC₅₀s of 0.82 μM and 1.2 μM in OVCAR-3 and Caov-4 ovarian cancer cells. Further, IB-MECA exhibited antiproliferative effect with IC₅₀s of 32.14 μM and 45.37 μM for OVCAR-3 and Caov-4 ovarian cancer cells, respectively. 48 h treatment with IB-MECA induced apoptosis in those cell lines with dosage range 0.1-100 μM and significantly reduced cell viability in a dose-dependent manner with dosage range 0.0001-100 μM^[3]. In B10CBAF1 male mice aged 3 months, IB-MECA (105 μg/kg) resulted in statistically significant increases of the mean survival time in comparison with the control irradiated mice^[4].