CAS:1010411-21-8GSK369796 Dihydrochloride

GSK369796 is an anti-malaria drug candidate.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

技术信息

CAS号

1010411-21-8

储存条件

分子式

C20H24Cl3N3O

运输

蓝冰

分子量

428.78

别名

溶解度

DMSO	95.0 mg/mL (221.6 mM)
Water	18.0 mg/mL (42.0 mM)

动物实验配方

生物活性

描述GSK369796 Dihydrochloride is an effective antimalarial. GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC50 of 7.5±0.8 μM. In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC50s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED50 and ED90 of 2.8 and 4.7 mg/kg, respectively. GSK369796 has high anti-DENV activity in the DENV2 replicon expressing cells with EC50 value of 5.06 ± 0.86 μM. The infectivity assays revealed the EC50 value of 3.03 ± 0.35 μM. Moreover, GSK369796 also showed antiviral activity against the rapidly emerging Zika virus (ZIKV) with EC50 value of 2.57 ± 0.09 μM.