CAS:1373423-53-0GSK-J4

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GSK-J4 Cat No. FB06732Cas No. 1373423-53-0

GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor and attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3952 mL
- 11.9760 mL
- 23.9521 mL
- 5 mM
- 0.4790 mL
- 2.3952 mL
- 4.7904 mL
- 10 mM
- 0.2395 mL
- 1.1976 mL
- 2.3952 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1373423-53-0

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C24H27N5O2

运输

蓝冰

分子量

417.50

别名

溶解度

DMSO	36.0 mg/mL (86.2 mM)

动物实验配方

靶点数据

生物活性

靶点 JMJD3

IC50:60nM
描述GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor and attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release).